November 01, 2020

Travel the length of the UK

This month we have motivated the department to help us run the length of the UK. We have asked everyone to record how much exercise they do each day, then see how far we travel collectively between us. Our team member Jack Elkes also built an R Shiny app to help us track our progress, follow the link below to check this out! 

October 19, 2020

Wanted: members of the public to advise our clinical trials research

We are setting up a group of public members to discuss how we can improve the information reported from clinical trials, so that it is more meaningful and usable for patients and the public. Often the numbers and statistics reported from trials are not well understood and we would like to understand how we can improve this. For more information on this opportunity and how to get involved please see the poster linked below.

August 31, 2020

NISS Meeting on Estimands and Missing Data

On September 1st, the National Institute of Statistical Science (NISS) held an online meeting to investigate topics related to methods or strategies for mitigating disruptions in trials during covid-19, as part of their Ingram Olkin Forum Series. Presenters included Suzie Cro who explored a strategy for handling unplanned disruptions in the analysis of trials using missing data methods. Other presenters included Mouna Akacha (Novartis), who discussed the value of the estimand framework (ICH 2019) in being able to support the proper analysis and interpretation of trials disrupted by covid-19, and David Murray, (Office of Disease Prevention) who provided examples from the Health Care Systems Collaboratory Project and reviewed how these trials adapted in response to various disruptions.

July 05, 2020

Recommendations to visualise treatment harm profiles in Randomised Controlled Trials – a national consensus

In collaboration with the UKCRC CTU Statistics Operation group, Rachel Phillips, Victoria Cornelius and Suzie Cro hosted three half day meetings to develop a national consensus of recommendations to display harm events in Randomised Controlled Trials. The meeting was attended by national senior statisticians from academia and industry, and delegates with info-graphic expertise.  The groups’ aim is to develop practical guidelines to support clinical trial researchers in their choice of visualisations for communicating AE data in publications. The next stage will seek input from clinicians and patients and the group will be publishing their work for trialists later this year.

June 24, 2020

A dose-finding design for early phase trials with continuous re-assessment

As part of the NIHR Statistics – Early Phase Trials Group webinar series on “Practical applications of advanced designs in Phase I Trials” Suzie Cro shared her recent experience of designing a dose finding study. The trial requires two agents to be combined where one has discrete dose levels and the other having doses that are patient specific. In the presentation Suzie Cro and Pavel Mozgunov from Lancaster University explained how they will evaluate the different discrete doses of the primary agent and allow for different ranges of the patient specific doses of the second agent.

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