Exploring the effect of COVID-19 restrictions on the Social Functioning Scale in a clinical trial of Antipsychotic Reduction: using multiple imputation to target a hypothetical estimand

Louise Marston, Joanna Moncrieff, Stefan Priebe, Suzie Cro, Victoria R. Cornelius

Many trials are affected by unforeseen events after recruitment has commenced. The aim of this study is to explore a hypothetical strategy for dealing with an intercurrent event that occurred during trial follow-up; COVID-19 restrictions. Analysis was conducted using multiple imputation.