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Statistical Methods for Contemporary Clinical Trials
FORWARDS-1: an adaptive, single-blind, placebo-controlled ascending dose study of acute baclofen on safety parameters in opioid dependence during methadone-maintenance treatment—a pharmacokinetic-pharmacodynamic study
L. M. Paterson, D. Barker, S. Cro, P. Mozgunov, R. Phillips, C. Smith, L. Nahar, S. Paterson & A. R. Lingford-Hughes
A protocol for a novel, adaptive, Bayesian model-based dose finding trial in opiate detoxification, including use of the estimand framework.
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