Statistical Methods for Contemporary Clinical Trials
Tools to help patients and other stakeholders’ input into choice of intercurrent event strategy for estimands in randomised trials
Joanna Hindley, Charlotte Hartley, Jennifer Hellier, Kate Sturgeon, Sophie Greenwood, Ian Newsome, Katherine Barrett, Debs Smith, Tra My Pham, Dongquan Bi, Beatriz Goulao, Suzie Cro and Brennan C. Kahan
This article describes three tools that could facilitate conversations between researchers and patients and other stakeholders about the choice of intercurrent event strategy for estimands: (i) a video explaining the concept of an estimand and the five different ways that intercurrent events can be incorporated into the estimand definition; (ii) an infographic outlining these five strategies; and (iii) an editable PowerPoint slide which can be completed with trial-specific details to facilitate conversations around choice of estimand for a particular trial.