Small Population Trials / Bayesian Methods

Eliciting Informed Priors for Small Population RCTs

Phase I: Assessing current use of Bayesian methods in rare disease and small population randomised controlled trials (RCTs).

Team: Giles Partington, Alexina Mason, Suzie Cro, Victoria Cornelius

A systematic review of late phase randomised control trials self reporting as small population or rare disease. This will investigate to what extent and how Bayesian methods are in use and otherwise what is being done to overcome issues raised by small populations in the frequentist setting.

The findings from this review will be added once published.