Clinical trials aim to draw conclusions about the effects of treatments, but typically events after randomisation, such as treatment discontinuations or rescue medication usage, affect the interpretation of results. Different trial designs and analyses can then address different questions, which can lead to quite different conclusions on treatment benefit for the same treatment. 

 

To ensure trials address the clinical questions of interest, a new international drug trial guideline, the ICH-E9(R1) addendum, introduced the estimand framework to align planning, design, conduct, analysis and interpretation.

 

We are holding a free online meeting for clinicians and statisticians in clinical trials to introduce estimands and why they are important. Followed by a free online workshop on how to implement the estimand framework.

 

The meeting on day 1 will include presentations from statisticians, clinicians and trial methodologists including:

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• Professor Amanda Adler (Director of Diabetes Trials Unit, University of Oxford)

• Dr Thinzar Min (Senior Clinical Lecturer, University of Swansea)

• Chrissie Fletcher (Vice President, Statistics, GSK)

• Dr Suzie Cro (Advanced Research Fellow and statistician, Imperial College London)

• Dr Brennan Kahan (Senior Research Fellow and statistician, MRC CTU @ UCL) 

• Dr Victoria Cornelius (Reader in Medical Statistics, Imperial College London)

 

The workshop on day 2 will include presentations from statisticians, break out group practical sessions and panel discussions, additionally including:

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• Professor James Carpenter (Professor of Medical Statistics, MRC CTU @ UCL) 

• Professor Ian White (Professor of Statistical Methods for Medicine, MRC CTU @ UCL) 

• Dr Helle Lynggaard & Bryan Goldman (Principal Statistician, Novo Nordisk)

• Professor Richard Emsley (Professor of Medical Statistics and Trials Methodology, Kings College London)

• Dr Beatriz Goulao (Research fellow and statistician, University of Aberdeen)

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Day 1 is open to all whilst places on the day 2 workshop are limited & available on a first come first served basis with priority for UK clinical trial unit affiliation and 2 places per institution in first instance.

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>Download the programme overview for more details on the events and learning aims here (coming soon)

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>Download the flyer for the events here (coming soon)

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>To register enter your details here (coming soon)

 

For all event enquiries please contact Ruthie Parsons: r.parsons21@imperial.ac.uk

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These events are free to attend and funded by the MRC NIHR Trials Methodology Research Partnership.

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